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Targeted Allele Detail
Symbol: Isl2tm2Slp
Name: insulin related protein 2 (islet 2); targeted mutation 2, Samuel L Pfaff
MGI ID: MGI:3046260
Synonyms: Isl2-
Gene: Isl2  Location: Chr9:55445956-55453464 bp, + strand  Genetic Position: Chr9, 30.13 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:89755
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 4, 5, and 6, which encode the homeodomain and C terminus were replaced with a neomycin resistance cassette. No protein could be detected in homozygous embryos. (J:89755)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isl2 Mutation:  17 strains or lines available
Original:  J:89755 Thaler JP, et al., A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron. 2004 Feb 5;41(3):337-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory