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Sycntm1Rja
Targeted Allele Detail
Nomenclature
Symbol: Sycntm1Rja
Name: syncollin; targeted mutation 1, Reinhard Jahn
MGI ID: MGI:3046204
Gene: Sycn  Location: Chr7:28540885-28542209 bp, + strand  Genetic Position: Chr7, 16.83 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74654
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, encoding residues 1-132, was replaced by a neomycin selection cassette. Western blot analysis on zymogen granules derived from adult homozygous mice confirmed that no detectable protein was expressed from this allele. (J:74654)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sycn Mutation:  7 strains or lines available
References
Original:  J:74654 Antonin W, et al., Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Mol Cell Biol. 2002 Mar;22(5):1545-54
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory