About   Help   FAQ
Hoxb4tm1.1Karl
Targeted Allele Detail
Nomenclature
Symbol: Hoxb4tm1.1Karl
Name: homeobox B4; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:3045971
Synonyms: Hoxb4-
Gene: Hoxb4  Location: Chr11:96318267-96321638 bp, + strand  Genetic Position: Chr11, 59.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90976
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTransient cre activity excised floxed exons 1 and 2 and a floxed neo, leaving a single loxp site. RT-PCR demonstrated absence of transcript in mutant mice. (J:90976)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxb4 Mutation:  12 strains or lines available
References
Original:  J:90976 Brun AC, et al., Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004 Jun 1;103(11):4126-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory