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Hoxb4tm1.1Karl
Targeted Allele Detail
Summary
Symbol: Hoxb4tm1.1Karl
Name: homeobox B4; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:3045971
Synonyms: Hoxb4-
Gene: Hoxb4  Location: Chr11:96209093-96212464 bp, + strand  Genetic Position: Chr11, 59.83 cM
Alliance: Hoxb4tm1.1Karl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90976
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsTransient cre activity excised floxed exons 1 and 2 and a floxed neo, leaving a single loxp site. RT-PCR demonstrated absence of transcript in mutant mice. (J:90976)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxb4 Mutation:  18 strains or lines available
References
Original:  J:90976 Brun AC, et al., Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells. Blood. 2004 Jun 1;103(11):4126-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory