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Sfrp1tm1Bsk
Targeted Allele Detail
Nomenclature
Symbol: Sfrp1tm1Bsk
Name: secreted frizzled-related protein 1; targeted mutation 1, Barry S Komm
MGI ID: MGI:3045799
Synonyms: sFRP-1-
Gene: Sfrp1  Location: Chr8:23411502-23449632 bp, + strand  Genetic Position: Chr8, 11.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89547
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, which encodes most of the protein and the entire CRD, was replaced by a LacZ/MC1-neo cassette. PCR analysis demonstrated that homozygous mutants contained the LacZ gene. Northern blot of kidneys indicated no presence of transcript for the CRD domain of the endogenous gene. RT-PCR analysis of calvaria showed lack of expression of both the CRD (the 5' region of the transcript) and the netrin domain (the 3' region) in mutants. (J:89547)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 85 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfrp1 Mutation:  5 strains or lines available
References
Original:  J:89547 Bodine PV, et al., The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol Endocrinol. 2004 May;18(5):1222-37
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory