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Rfx3tm2.1Wrth
Targeted Allele Detail
Nomenclature
Symbol: Rfx3tm2.1Wrth
Name: regulatory factor X, 3 (influences HLA class II expression); targeted mutation 2.1 W Reith
MGI ID: MGI:3045794
Synonyms: Rfx3-
Gene: Rfx3  Location: Chr19:27766441-28011166 bp, - strand  Genetic Position: Chr19, 22.36 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89880
Parent Cell Line:  ENS (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre-mediated recombination of Rfx3tm2Wrth resulted in the excision of floxed exon 3, which encodes the DNA binding domain. RT-PCR showed that the deletion of exon 3 resulted in the splicing of exon 2 to exon 4, leading to a frameshift and premature termination at an out-of-frame stop codon. (J:89880)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfx3 Mutation:  48 strains or lines available
References
Original:  J:89880 Bonnafe E, et al., The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol. 2004 May;24(10):4417-27
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory