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RplagFVB/NJ
QTL Variant Detail
Nomenclature
QTL variant: RplagFVB/NJ
Name: reduced platelet aggregation; FVB/NJ
MGI ID: MGI:3045767
QTL: Rplag  Location: Chr13:112365596-112365710 bp  Genetic Position: Chr13, cM position of peak correlated region/allele: 63.73 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  FVB/NJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased platelet Itga2 expression compared to C57BL/6J. (J:90287)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:90287

Inbred strain FVB/NJ expresses 50% less integrin alpha 2 on blood platelets compared to inbred strains C57BL/6J, 129X1/SvJ, C3H/HeJ, and BALB/cJ. Platelets from FVB/NJ mice exhibit reduced collagen-induced aggregation and longer lag time to collagen compared to other strains. Twenty (FVB/NJ x C57BL/6J)F2 animals were typed for D13Mit260, a marker at 83 cM on mouse Chromosome 13 near the Itga2 gene. D13Mit260 showed linkage to reduced Itga2 expression with LOD=6.7 and this locus is named Rplag (reduced platelet aggregation). Authors theorize polymorphisms in the Itga2 regulatory region may be responsible for the 2-fold reduction in integrin alpha 2 expression and reduced platelet aggregation phenotype observed in FVB/NJ mice.

References
Original:  J:90287 Li TT, et al., Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. Blood. 2004 May 1;103(9):3396-402
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory