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Tlr12tm1Gho
Targeted Allele Detail
Nomenclature
Symbol: Tlr12tm1Gho
Name: toll-like receptor 12; targeted mutation 1, Sankar Ghosh
MGI ID: MGI:3045751
Synonyms: TLR11-
Gene: Tlr12  Location: Chr4:128615443-128618619 bp, - strand  Genetic Position: Chr4, 62.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89754
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCoding sequence was replaced with a neomycin selection cassette through homologous recombination. RT-PCR analysis on kidney mRNA derived from homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:89754)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlr12 Mutation:  12 strains or lines available
Notes
Confusion exists regarding the identity of Tlr11 and Tlr12. All of the references listed below identify this allele as an allele of Tlr11. However, all of the associated sequence information indicates that this is, in fact, an allele of Tlr12. J:89754 J:113110 J:114880 J:125088 J:142066 J:150494
References
Original:  J:89754 Zhang D, et al., A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5;303(5663):1522-6
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory