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Tg(Pax6-cre,GFP)1Pgr
Transgene Detail
Nomenclature
Symbol: Tg(Pax6-cre,GFP)1Pgr
Name: transgene insertion 1, Peter Gruss
MGI ID: MGI:3045749
Synonyms: Le-Cre, Le-Cre-GFP, Lens-Cre, P0-3.9-GFPCre, Pax6Cre, Pax6(LP)-Cre, Tg(Pax6-cre,GFP)1Pgr
Transgene: Tg(Pax6-cre,GFP)1Pgr  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a 6.5 kb genomic fragment upstream of the murine Pax6 gene, an nlsCre, an IRES, EGFP, and a polyadenylation signal. The Pax6 promoter fragment drives expression of Cre and GFP in the surface ectoderm, developing lens, cornea, and pancreas in transgenic mice. (J:65765)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pax6     Summary of all recombinase alleles driven by Pax6. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 36 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:65765 Ashery-Padan R, et al., Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000 Nov 1;14(21):2701-11
All:  122 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory