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Tlr7tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Tlr7tm1Aki
Name: toll-like receptor 7; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3045662
Synonyms: Tlr7-
Gene: Tlr7  Location: ChrX:167304929-167330558 bp, - strand  Genetic Position: ChrX, 78.31 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90979
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo replaced 1.8 kb of sequence that encodes a part of a leucine-rich repeat by homologous recombination. Recombination was confirmed by Southern analysis of tails from mutant males. (J:90979)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tlr7 Mutation:  11 strains or lines available
References
Original:  J:90979 Hemmi H, et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200
All:  96 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory