Gfra3^tm1Wss
Targeted Allele Detail

Summary

• Symbol: Gfra3^tm1Wss
• Name: glial cell line derived neurotrophic factor family receptor alpha 3; targeted mutation 1, W Scott Simonet
• MGI ID: MGI:3045508
• Gene: Gfra3 Location: Chr18:34822951-34853440 bp, - strand Genetic Position: Chr18, 18.69 cM
• Alliance: Gfra3^tm1Wss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90843
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 11 kb segment of the gene including exons 1 and 2 and encoding amino acids 2 to 123 was replaced with a lacZ/neo cassette. The cassette was fused in frame. Recombination was confirmed by Southern blot and PCR and RT-PCR indicated absence of gene expression in mutant mice. (J:90843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra3 Mutation: 31 strains or lines available

References

• Original: J:90843 Bolon B, et al., The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol. 2004 May-Jun;32(3):275-94
• All: 1 reference(s)