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Cnr1tm1.2Ltz
Targeted Allele Detail
Nomenclature
Symbol: Cnr1tm1.2Ltz
Name: cannabinoid receptor 1 (brain); targeted mutation 1.2, Beat Lutz
MGI ID: MGI:3045419
Synonyms: CB1f
Gene: Cnr1  Location: Chr4:33924593-33948831 bp, + strand  Genetic Position: Chr4, 16.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89842
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThis allele was generated by breeding mice homozygous for Cnr1tm1Ltz with transgenic mice ubiquitously expressing flip recombinase, thereby leaving the floxed coding region. Southern blot and PCR analysis confirmed recombination. mRNA was present in pyramidal neurons. (J:89842)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnr1 Mutation:  21 strains or lines available
References
Original:  J:89842 Marsicano G, et al., CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science. 2003 Oct 3;302(5642):84-8
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory