Tg(Fabp4-SREBP1a)2Reh
Transgene Detail

Summary

• Symbol: Tg(Fabp4-SREBP1a)2Reh
• Name: transgene insertion 2, Robert E Hammer
• MGI ID: MGI:3045407
• Synonyms: aP2-SREBP-1a, B line
• Transgene: Tg(Fabp4-SREBP1a)2Reh Location: unknown
• Alliance: Tg(Fabp4-SREBP1a)2Reh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp4-SREBP1a)2Reh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

• Mutation details: This transgene overexpresses a transcriptionally active fragment of the human SREBP-1a gene under the control of a mouse adipose-specific promoter/enhancer of the Fabp4 gene. This truncated form of the SREBP-1a gene lacks the membrane attachment domain and translocates to the nucleus without proteolytic processing. Northern blot analysis demonstrated that the transgene was abundantly expressed in both white and brown adipose tissue, although at lower levels than the A line. (J:85534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85534 Horton JD, et al., Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem. 2003 Sep 19;278(38):36652-60
• All: 1 reference(s)