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Fastm1Dlo
Targeted Allele Detail
Nomenclature
Symbol: Fastm1Dlo
Name: Fas (TNF receptor superfamily member 6); targeted mutation 1, Dennis Y Loh
MGI ID: MGI:3045400
Synonyms: Fas-
Gene: Fas  Location: Chr19:34290666-34327772 bp, + strand  Genetic Position: Chr19, 29.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31847
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire gene except for exon 1, which encodes half of the signal peptide, was replaced with a PGK-neo-poly(A) cassette. Absence of protein in mutants was confirmed by flow cytometry. (J:31847)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fas Mutation:  53 strains or lines available
References
Original:  J:31847 Senju S, et al., Functional significance of the Fas molecule in naive lymphocytes. Int Immunol. 1996 Mar;8(3):423-31
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory