Lpl^tm1Ijg
Targeted Allele Detail

Summary

• Symbol: Lpl^tm1Ijg
• Name: lipoprotein lipase; targeted mutation 1, Ira J Goldberg
• MGI ID: MGI:3045235
• Synonyms: Lpl loxP
• Gene: Lpl Location: Chr8:69333207-69359584 bp, + strand Genetic Position: Chr8, 33.88 cM
• Alliance: Lpl^tm1Ijg page

Increase in interstitial and perivascular collagen in Lpl^tm1Ijg/Lpl^tm1Ijg Tg(Myh6-cre)2182Mds/0 hearts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90737
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was introduced into intron 1 and a floxed neo was inserted upstream of exon 1. Transient cre excised the floxed neo, leaving floxed exon 1. Southern blot confirmed recombination and Northern blot demonstrated presence of RNA. (J:90737)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lpl Mutation: 43 strains or lines available

References

• Original: J:90737 Augustus A, et al., Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem. 2004 Jun 11;279(24):25050-7
• All: 34 reference(s)