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Jak2tm1Kpf
Targeted Allele Detail
Nomenclature
Symbol: Jak2tm1Kpf
Name: Janus kinase 2; targeted mutation 1, Klaus Pfeffer
MGI ID: MGI:3045167
Synonyms: Jak2-
Gene: Jak2  Location: Chr19:29251828-29313080 bp, + strand  Genetic Position: Chr19, 23.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47298
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced the start codon and downstream sequence from exon 1. Protein was undetected by Western blot analysis of homozygous mutant embryonic fibroblasts. (J:47298)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  18 strains or lines available
References
Original:  J:47298 Neubauer H, et al., Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998 May 1;93(3):397-409
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory