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Pgia40BALB/cCrl
QTL Variant Detail
Nomenclature
QTL variant: Pgia40BALB/cCrl
Name: proteoglycan induced arthritis 40; BALB/cCrl
MGI ID: MGI:3044994
QTL: Pgia40  Location: Chr13:44918469-44918560 bp  Genetic Position: Chr13, Syntenic
Variant
origin
Strain of Specimen:  BALB/cCrl
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:84150

Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

The authors cite the following marker as having been previously mapped; however, differing parental strains were used in the previous map studies. We have renamed the QTL as follows:

The authors refer to Pgia15 on Chromosome 13. This QTL was originally mapped using (C57BL/6x C3H/HeJCr)F2 intercrossd mice in J:65424. We have renamed this QTL, mapped here using (BALB/cCrl x DBA/2Crl)F2, as Pgia40. This QTL maps to mouse chromosome 13 at D13Mit179 with a LOD=4.1 in female mice for disease suceptibility. The Pgia40 interval spanned 0-47cM on chr 13.

References
Original:  J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory