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QTL Variant Detail
QTL variant: Pgia40BALB/cCrl
Name: proteoglycan induced arthritis 40; BALB/cCrl
MGI ID: MGI:3044994
QTL: Pgia40  Location: Chr13:44918469-44918560 bp  Genetic Position: Chr13, Syntenic
Strain of Specimen:  BALB/cCrl
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.

Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.

The authors cite the following marker as having been previously mapped; however, differing parental strains were used in the previous map studies. We have renamed the QTL as follows:

The authors refer to Pgia15 on Chromosome 13. This QTL was originally mapped using (C57BL/6x C3H/HeJCr)F2 intercrossd mice in J:65424. We have renamed this QTL, mapped here using (BALB/cCrl x DBA/2Crl)F2, as Pgia40. This QTL maps to mouse chromosome 13 at D13Mit179 with a LOD=4.1 in female mice for disease suceptibility. The Pgia40 interval spanned 0-47cM on chr 13.

Original:  J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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