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Targeted Allele Detail
Symbol: Notch1tm2Rko
Name: notch 1; targeted mutation 2, Raphael Kopan
MGI ID: MGI:3044585
Synonyms: fN1, N1f, NICD1fl, Notch1f, Notch1flox, Notch1tm1Shn
Gene: Notch1  Location: Chr2:26457902-26503822 bp, - strand  Genetic Position: Chr2, 18.91 cM
Corneal plaques and increased angiogenesis in the ear of Notch1tm2Rko/Notch1tm3(cre)Rko mice

Show the 7 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:90392
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsLoxP were inserted flanking the first coding exon of the gene. An adjacent loxP flanked neomycin cassette was removed by Cre-mediated recombination in ES cells prior to production of chimeric animals. (J:90392)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 55000 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  36 strains or lines available
Original:  J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
All:  103 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory