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Tg(TcraH-Y,TcrbH-Y)71Vbo
Transgene Detail
Nomenclature
Symbol: Tg(TcraH-Y,TcrbH-Y)71Vbo
Name: transgene insertion 71, Harald von Boehmer
MGI ID: MGI:3044562
Synonyms: B6.2.16, HY, H-Y, HY1.1, HY1.1 (Tcr-ab), H-Y TCR, HY TCR, HY-TCR, HyTcrTg, HY_TCRtg, H-Y Tg, T-cell receptor (alpha/beta) anti-Hy, TCR HY, Tg71
Transgene: Tg(TcraH-Y,TcrbH-Y)71Vbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraH-Y,TcrbH-Y)71Vbo expresses 2 genes
 
Mutation detailsThe two transgenes comprise functionally rearranged T-cell receptor alpha and T-cell receptor beta genes, isolated from the cytotoxic T cell clone B6.2.16, that recognize the male-specific H-Y antigen in the context of the H2-Db major histocompatibilty protein. The alpha chain transgene has the V-alpha3 gene segment joined to the J-alpha27 segment; the beta chain transgene joins V-beta8.2, D-beta1, J-beta2.3 and C-beta2. The two transgenes were coinjected into fertilized oocytes. The founder of line 71 carried four copies of the rearranged T-cell receptor alpha and two copies of the T-cell receptor beta transgenes. (J:51117, J:79738, J:90776)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
References
Original:  J:79738 Kisielow P, et al., Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature. 1988 Jun 23;333(6175):742-6
All:  215 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory