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Fgfr2tm1.1Dor
Targeted Allele Detail
Nomenclature
Symbol: Fgfr2tm1.1Dor
Name: fibroblast growth factor receptor 2; targeted mutation 1.1, David M Ornitz
MGI ID: MGI:3044427
Synonyms: Fgfr2delta
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90391
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre mediated recombination of Fgfr2tm1Dor was used to excise exons 7-10, which encode the alternatively spliced Ig domain IIIb, IIIc and TM domain. PCR analysis confirmed recombination in tails of mutants. (J:90391)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  20 strains or lines available
References
Original:  J:90391 Yu K, et al., Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003 Jul;130(13):3063-74
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory