Fgfr2^tm1.1Dor
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm1.1Dor
• Name: fibroblast growth factor receptor 2; targeted mutation 1.1, David M Ornitz
• MGI ID: MGI:3044427
• Synonyms: Fgfr2^delta
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm1.1Dor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90391
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination of Fgfr2^tm1Dor was used to excise exons 7-10, which encode the alternatively spliced Ig domain IIIb, IIIc and TM domain. PCR analysis confirmed recombination in tails of mutants. (J:90391)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 87 strains or lines available

References

• Original: J:90391 Yu K, et al., Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003 Jul;130(13):3063-74
• All: 18 reference(s)