Twist2tm1(cre)Dor
Targeted Allele Detail
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Symbol: |
Twist2tm1(cre)Dor |
Name: |
twist basic helix-loop-helix transcription factor 2; targeted mutation 1, David M Ornitz |
MGI ID: |
MGI:3044412 |
Synonyms: |
Dermo1cre, Dermo1Cre, Dermo-1Cre, Dermo1-Cre, Dermocre, DM1-Cre, twist-2-, Twist2tm1(cre)Eno |
Gene: |
Twist2 Location: Chr1:91729183-91775750 bp, + strand Genetic Position: Chr1, 46.24 cM
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Alliance: |
Twist2tm1(cre)Dor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:81485
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Twist2tm1(cre)Dor expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Twist2 (MGI:104685) |
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Mutation details: Exon 1 was replaced with a cre recombinase gene and an FRT-flanked neo cassette. Southern blot analysis confirmed recombination. Cre was expressed in the developing skeleton, specifically in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages.
(J:90391)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Twist2
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Twist2 Mutation: |
10 strains or lines available
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Original: |
J:81485 Sosic D, et al., Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 2003 Jan 24;112(2):169-80 |
All: |
83 reference(s) |
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