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Spontaneous Allele Detail
Symbol: rsl
Name: regulator of sex limited protein-Slp
MGI ID: MGI:3044189
Synonyms: Rsl1-, rslFM, rslPL
Gene: rsl  Location: Chr13:56481436-72237021 bp  Genetic Position: Chr13, Syntenic
Strain of Origin:  multiple strains
Allele Type:    Spontaneous
Mutation:    Other
Mutation detailsThe Slp gene is normally expressed in male mice, but it is expressed in females in the strains FM, LG, NZB, and PL due to a mutation in the rsl gene(s). The rsl (regulator of sex limited protein-Slp) phenotype is attributable to mutations in both the Rsl1 and Rsl2 genes. Both a small deletion of Rsl2 and a G-to-T transversion mutation that affects transcript splicing of Rsl1 appear to affect sexually dimorphic expression of male-specific genes, although only the mutation in Rsl1 appears to cause the loss of sex-limited expression of Slp. (J:86324)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any rsl Mutation:  1 strain or line available
Original:  J:84442 Brown LJ, et al., Female expression of the H-2-linked sex-limited protein (Slp) due to non-H-2 genes. Immunogenetics. 1980;10(1):19-29
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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