Wfs1^tm1Yoka
Targeted Allele Detail

Summary

• Symbol: Wfs1^tm1Yoka
• Name: wolframin ER transmembrane glycoprotein; targeted mutation 1, Yoshitomo Oka
• MGI ID: MGI:3044175
• Synonyms: wfs1-
• Gene: Wfs1 Location: Chr5:37123448-37146326 bp, - strand Genetic Position: Chr5, 19.46 cM
• Alliance: Wfs1^tm1Yoka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90420
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin-resistance gene was inserted into the second exon, which contains the initial ATG codon. Western blot indicated absence of protein in mutant brains. (J:90420)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wfs1 Mutation: 43 strains or lines available

References

• Original: J:90420 Ishihara H, et al., Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion. Hum Mol Genet. 2004 Jun 1;13(11):1159-70
• All: 9 reference(s)