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Amacrtm1Jkh
Targeted Allele Detail
Nomenclature
Symbol: Amacrtm1Jkh
Name: alpha-methylacyl-CoA racemase; targeted mutation 1, J Kalervo Hiltunen
MGI ID: MGI:3044171
Gene: Amacr  Location: Chr15:10981756-10996624 bp, + strand  Genetic Position: Chr15, 5.39 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90370
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 were replaced with a neomycin selection cassette. Real-time PCR showed lack of transcript in mutant mice. Immunoblotting demonstrated lack of protein in mutant liver and kidney. (J:90370)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Amacr Mutation:  9 strains or lines available
References
Original:  J:90370 Savolainen K, et al., A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids. Hum Mol Genet. 2004 May 1;13(9):955-65
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory