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Trhrtm1Bau
Targeted Allele Detail
Nomenclature
Symbol: Trhrtm1Bau
Name: thyrotropin releasing hormone receptor; targeted mutation 1, Karl Bauer
MGI ID: MGI:3044170
Synonyms: THR-R1-, trhr1ko
Gene: Trhr  Location: Chr15:44196135-44235912 bp, + strand  Genetic Position: Chr15, 16.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90365
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe complete coding region encompassing the transcriptional start site in exon 2 and spanning part of exon 5 was replaced with LacZ and neo cassettes. Northern blot confirmed absence of transcript in pituitary glands of mutants. (J:90365)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trhr Mutation:  20 strains or lines available
References
Original:  J:90365 Rabeler R, et al., Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol. 2004 Jun;18(6):1450-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory