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Targeted Allele Detail
Symbol: Tfe3tm1Est
Name: transcription factor E3; targeted mutation 1, Eirikur Steingrimsson
MGI ID: MGI:3044119
Synonyms: Tcfe3-, Tfe3Fcr
Gene: Tfe3  Location: ChrX:7762560-7775202 bp, + strand  Genetic Position: ChrX, 3.5 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:89821
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 5.5 kb genomic fragment encompassing 7 exons and encoding the bHLH-Zip domains was replaced with a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of renal RNA obtained from hemizygous mutant mice. (J:89821)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tfe3 Mutation:  20 strains or lines available
Original:  J:89821 Steingrimsson E, et al., Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4477-82
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory