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Mutyhtm1Jhmi
Targeted Allele Detail
Nomenclature
Symbol: Mutyhtm1Jhmi
Name: mutY DNA glycosylase; targeted mutation 1, Jeffrey H Miller
MGI ID: MGI:3043929
Synonyms: Myh-
Gene: Mutyh  Location: Chr4:116807723-116819440 bp, + strand  Genetic Position: Chr4, 53.34 cM, cytoband C7
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89742
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 6, which encodes a conserved pseudo-helix-hairpin-helix motif, was disrupted by the insertion of a neo cassette. Transcript was undetected by RT-PCR analysis of RNA obtained from the livers of homozygous mutant mice. (J:89742)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mutyh Mutation:  28 strains or lines available
References
Original:  J:89742 Xie Y, et al., Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 1;64(9):3096-102
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory