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Targeted Allele Detail
Symbol: Cd274tm1Lpc
Name: CD274 antigen; targeted mutation 1, Lieping Chen
MGI ID: MGI:3043876
Synonyms: B7-H1-, Cd274-Ko, Cd274null
Gene: Cd274  Location: Chr19:29344855-29365495 bp, + strand  Genetic Position: Chr19, 23.88 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:89781
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, encoding the start codon and signal peptide, and a portion of exon 2, encoding the IgV domain, were replaced with a neo cassette inserted by homologous recombination. Protein was undetected on the surface of homozygous mutant CD4+ T cells via flow cytometric analysis. Western blot analysis further confirmed the absence of normal protein in homozygous mutant mice. (J:89781)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd274 Mutation:  54 strains or lines available
Original:  J:89781 Dong H, et al., B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 2004 Mar;20(3):327-36
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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