Asic2^tm1Lzd
Targeted Allele Detail

Summary

• Symbol: Asic2^tm1Lzd
• Name: acid-sensing ion channel 2; targeted mutation 1, Michel Lazdunski
• MGI ID: MGI:3043847
• Gene: Asic2 Location: Chr11:80770989-81859222 bp, - strand Genetic Position: Chr11, 48.43 cM
• Alliance: Asic2^tm1Lzd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90117
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene was inserted downstream of the exon encoding the second transmembrane domain. A third loxP site was inserted upstream from this exon. (J:90117)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asic2 Mutation: 38 strains or lines available

References

• Original: J:90117 Ettaiche M, et al., Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J Neurosci. 2004 Feb 4;24(5):1005-12
• All: 1 reference(s)