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Slc6a18tm1Mca
Targeted Allele Detail
Nomenclature
Symbol: Slc6a18tm1Mca
Name: solute carrier family 6 (neurotransmitter transporter), member 18; targeted mutation 1, Marc G Caron
MGI ID: MGI:3043846
Synonyms: XT2-/-
Gene: Slc6a18  Location: Chr13:73661752-73678023 bp, - strand  Genetic Position: Chr13, 40.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89891
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site remained in place of a genomic fragment encompassing exon 1 and a portion of intron 1 after a floxed neo cassette was excised via cre-mediated recombination. Absence of mRNA expression in homozygous mutant mice was verified by RT-PCR analysis. (J:89891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a18 Mutation:  1 strain or line available
References
Original:  J:89891 Quan H, et al., Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol. 2004 May;24(10):4166-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory