About   Help   FAQ
Slc6a18tm1Mca
Targeted Allele Detail
Nomenclature
Symbol: Slc6a18tm1Mca
Name: solute carrier family 6 (neurotransmitter transporter), member 18; targeted mutation 1, Marc G Caron
MGI ID: MGI:3043846
Synonyms: XT2-/-
Gene: Slc6a18  Location: Chr13:73661752-73678023 bp, - strand  Genetic Position: Chr13, 40.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89891
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site remained in place of a genomic fragment encompassing exon 1 and a portion of intron 1 after a floxed neo cassette was excised via cre-mediated recombination. Absence of mRNA expression in homozygous mutant mice was verified by RT-PCR analysis. (J:89891)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a18 Mutation:  16 strains or lines available
References
Original:  J:89891 Quan H, et al., Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol. 2004 May;24(10):4166-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory