Cdk5^tm2Kul
Targeted Allele Detail

Summary

• Symbol: Cdk5^tm2Kul
• Name: cyclin dependent kinase 5; targeted mutation 2, Ashok B Kulkarni
• MGI ID: MGI:3043819
• Synonyms: Cdk5^loxP, fCdk5
• Gene: Cdk5 Location: Chr5:24623239-24628528 bp, - strand Genetic Position: Chr5, 11.73 cM, cytoband A3-B1
• Alliance: Cdk5^tm2Kul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89561
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A genomic fragment encompassing all exons was flanked by single loxP sites, located 2 kb upstream of exon 1 and 3kb downstream of the last exon. (J:89561)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk5 Mutation: 15 strains or lines available

References

• Original: J:89561 Hirasawa M, et al., Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6249-54
• All: 11 reference(s)