Runx2^tm1Ldq
Targeted Allele Detail

Summary

• Symbol: Runx2^tm1Ldq
• Name: runt related transcription factor 2; targeted mutation 1, L Darryl Quarles
• MGI ID: MGI:3043791
• Synonyms: Runx2-II-
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^tm1Ldq page

Skeletal abnormalities in Runx2^tm1Ldq/Runx2^tm1Ldq newborn mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89822
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The P1 promoter and exon 1 were replaced with a neo cassette via homologous recombination. This specifically deleted the Runx2-II isoform and not the Runx2-I isoform. Rt-PCR confirmed the absence of Runx2-II RNA and the presence of Runx2-I RNA. (J:89822, J:99696)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 42 strains or lines available

References

• Original: J:89822 Xiao ZS, et al., Selective deficiency of the 'bone-related' Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis. J Biol Chem. 2004 May 7;279(19):20307-13
• All: 4 reference(s)