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Runx2tm1Ldq
Targeted Allele Detail
Nomenclature
Symbol: Runx2tm1Ldq
Name: runt related transcription factor 2; targeted mutation 1, L Darryl Quarles
MGI ID: MGI:3043791
Synonyms: Runx2-II-
Gene: Runx2  Location: Chr17:44495987-44814797 bp, - strand  Genetic Position: Chr17, 21.33 cM
Skeletal abnormalities in Runx2tm1Ldq/Runx2tm1Ldq newborn mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89822
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe P1 promoter and exon 1 were replaced with a neo cassette via homologous recombination. This specifically deleted the Runx2-II isoform and not the Runx2-I isoform. Rt-PCR confirmed the absence of Runx2-II RNA and the presence of Runx2-I RNA. (J:89822, J:99696)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Runx2 Mutation:  2 strains or lines available
References
Original:  J:89822 Xiao ZS, et al., Selective deficiency of the 'bone-related' Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis. J Biol Chem. 2004 May 7;279(19):20307-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory