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Targeted Allele Detail
Symbol: Nr4a3tm1Wnt
Name: nuclear receptor subfamily 4, group A, member 3; targeted mutation 1, Astar Winoto
MGI ID: MGI:3043761
Synonyms: Nor-1 -
Gene: Nr4a3  Location: Chr4:48045153-48086447 bp, + strand  Genetic Position: Chr4, 26.07 cM, cytoband B2
Abnormal mesoderm accumulation in E7 Nr4a3tm1Wnt/Nr4a3tm1Wnt embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:89944
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 3 containing the transcriptional activation domain and part of the DNA binding domain was replaced with a neo cassette via homologous recombination. In situ hybridization confirmed the absence of RNA expression in homozygous embryos. (J:89944)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr4a3 Mutation:  1 strain or line available
Original:  J:89944 DeYoung RA, et al., The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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