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Targeted Allele Detail
Symbol: Ndrg1tm1Myta
Name: N-myc downstream regulated gene 1; targeted mutation 1, Toshiyuki Miyata
MGI ID: MGI:3043362
Synonyms: Ndrg1-
Gene: Ndrg1  Location: Chr15:66801167-66841489 bp, - strand  Genetic Position: Chr15, 29.3 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:89888
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxP site remained in place of a genomic fragment encompassing the promoter and exon 1 after cre-mediated excision of loxP sites inserted by homologus recombination. The start codon is contained within exon 2 and though neither transcript nor protein was detected in renal tissue via Northern or Western blot analysis, low levels of normal sized transcript and protein were detected in sciatic nerve. (J:89888)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndrg1 Mutation:  20 strains or lines available
Original:  J:89888 Okuda T, et al., Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Mol Cell Biol. 2004 May;24(9):3949-56
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory