Htt^tm3Detl
Targeted Allele Detail

Nomenclature

• Symbol: Htt^tm3Detl
• Name: huntingtin; targeted mutation 3, Peter J Detloff
• MGI ID: MGI:3043022
• Gene: Htt Location: Chr5:34761740-34912534 bp, + strand Genetic Position: Chr5, 17.92 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67074
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 and the promoter were replaced with an HPRT minigene. (J:67074)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 88 strains or lines available

References

• Original: J:67074 Lin CH, et al., Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum Mol Genet. 2001 Jan 15;10(2):137-44
• All: 2 reference(s)