Ckb^tm1Bew
Targeted Allele Detail

Summary

• Symbol: Ckb^tm1Bew
• Name: creatine kinase, brain; targeted mutation 1, Be Wieringa
• MGI ID: MGI:3042843
• Synonyms: B-CK-
• Gene: Ckb Location: Chr12:111635795-111638772 bp, - strand Genetic Position: Chr12, 61.09 cM
• Alliance: Ckb^tm1Bew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89399
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 including the translation start site was deleted and replaced with a neo-cassette via homologous recombination. Absence of RNA expression and enzyme activity were confirmed by northern blot analysis and activity assays. (J:89399)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ckb Mutation: 23 strains or lines available

References

• Original: J:89399 Jost CR, et al., Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Eur J Neurosci. 2002 May;15(10):1692-706
• All: 7 reference(s)