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Targeted Allele Detail
Symbol: Nrxn3tm1Sud
Name: neurexin III; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3042720
Gene: Nrxn3  Location: Chr12:88722876-90334935 bp, + strand  Genetic Position: Chr12, 42.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:89452
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS domain. Immunoblotting of mutant brain confirmed lack of protein expression. (J:89452)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn3 Mutation:  5 strains or lines available
Original:  J:89452 Missler M, et al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 2003 Jun 26;423(6943):939-48
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory