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Targeted Allele Detail
Symbol: Mapk3tm1Gela
Name: mitogen-activated protein kinase 3; targeted mutation 1, Gary Landreth
MGI ID: MGI:3042006
Synonyms: ERK1 -, Mapk3tm1Jsw, Mapk3tm1Tgf
Gene: Mapk3  Location: Chr7:126759601-126765819 bp, + strand  Genetic Position: Chr7, 69.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:77455
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Not Specified
Mutation detailsA targeting construct was designed to replace exons 1-6 of the protein coding sequence, including protein kinase domains I-X, with a neomycin resistance gene flanked by loxP sites. The null allele was confirmed by Western blot analysis. (J:77455, J:107504)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk3 Mutation:  12 strains or lines available
Original:  J:77455 Selcher JC, et al., Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem. 2001 Jan-Feb;8(1):11-9
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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