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Tg(Col1a1-cre)1Kry
Transgene Detail
Nomenclature
Symbol: Tg(Col1a1-cre)1Kry
Name: transgene insertion 1, Gerard Karsenty
MGI ID: MGI:3041864
Synonyms: 2.3kb alpha1(I)-cre, alpha1(1) collagen-Cre, alpha1(I)collagen-Cre, alpha1(I)-Cre, Col1a12.3kbCre, Col1-Cre, Col2.3-Cre, Col-Cre
Transgene: Tg(Col1a1-cre)1Kry  Location: unknown  Genetic Position: Chr14, Syntenic
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsSequence encoding cre recombinase was adjoined to 2.3 kb of the Col1a1 promoter. The endogenous Col1a1 promoter is active in osteoblasts throughout their differentiation and, accordingly, expression of cre recombinase was detected exclusively in bone. Cytogenetic mapping indicates that the transgene integrated on chromosome 14qE2-4. (J:77071, J:165282)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col1a1     Summary of all recombinase alleles driven by Col1a1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:77071 Dacquin R, et al., Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev Dyn. 2002 Jun;224(2):245-51
All:  114 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory