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Targeted Allele Detail
Symbol: Bmp4tm1Jfm
Name: bone morphogenetic protein 4; targeted mutation 1, James F Martin
MGI ID: MGI:3041440
Synonyms: Bmp4clc, Bmp4floxneo
Gene: Bmp4  Location: Chr14:46383525-46390669 bp, - strand  Genetic Position: Chr14, 23.95 cM
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:89237
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was introduced upstream of exon 4 and another loxP site followed by a FRT-flanked neo was inserted downstream of exon 4. PCR was used to confirm recombination. (J:89237)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 99 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:  17 strains or lines available
Original:  J:89237 Liu W, et al., Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4489-94
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory