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Mettm1Sst
Targeted Allele Detail
Nomenclature
Symbol: Mettm1Sst
Name: met proto-oncogene; targeted mutation 1, Snorri S Thorgeirsson
MGI ID: MGI:3041135
Synonyms: c-metfl, cMetlox, Metflx, Metlox
Gene: Met  Location: Chr6:17463800-17573980 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89236
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 16 was left flanked by single loxP sites following cre-mediated excision of floxed neo cassette from intron 16. (J:89236)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Met Mutation:  40 strains or lines available
References
Original:  J:89236 Huh CG, et al., Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004 Apr 30;101(13):4477-82
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory