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Il27ratm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Il27ratm1Mak
Name: interleukin 27 receptor, alpha; targeted mutation 1, Tak Mak
MGI ID: MGI:3040914
Synonyms: IL-27R-, Il27ra-, Wsx1-, WSX-1-
Gene: Il27ra  Location: Chr8:84030294-84042589 bp, - strand  Genetic Position: Chr8, 40.26 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89509
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn exon encoding a portion of the extracellular fibronectin type III domain was replaced with a neo cassette. Western blot demonstrated lack of protein in mutant spleen cells. (J:89509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il27ra Mutation:  11 strains or lines available
References
Original:  J:89509 Yoshida H, et al., WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 2001 Oct;15(4):569-78
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory