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Zfp148tm1Kii
Targeted Allele Detail
Nomenclature
Symbol: Zfp148tm1Kii
Name: zinc finger protein 148; targeted mutation 1, Ken-ichi Isobe
MGI ID: MGI:3040891
Gene: Zfp148  Location: Chr16:33380775-33503903 bp, + strand  Genetic Position: Chr16, 23.93 cM
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:81445
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 9, which makes up over 60% of the coding region, was replaced with a neo cassette via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. (J:81445)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zfp148 Mutation:  92 strains or lines available
Notes
Haploinsufficiency of Zfp148 prevents genetic transmission of the mutated allele and generation of non-chimeric heterozygous mice. All phenotype data reported are from chimeric mice.
References
Original:  J:81445 Takeuchi A, et al., Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat Genet. 2003 Feb;33(2):172-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory