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Ahnaktm1Vtm
Targeted Allele Detail
Nomenclature
Symbol: Ahnaktm1Vtm
Name: AHNAK nucleoprotein (desmoyokin); targeted mutation 1, Vincent T Marchesi
MGI ID: MGI:3040870
Synonyms: Ahnak-, Ahnak1-
Gene: Ahnak  Location: Chr19:8989284-9076919 bp, + strand  Genetic Position: Chr19, 6.04 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89231
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced 5.3 kb of sequence encompassing the putative promoter, 5' UTR, and a segment of the coding region. Northern blot of mutant heart ventricles indicated no transcript was present, and absence of normal protein was confirmed by immunoblot. (J:89231)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ahnak Mutation:  184 strains or lines available
References
Original:  J:89231 Komuro A, et al., The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4053-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory