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Ccnftm1.1Sje
Targeted Allele Detail
Nomenclature
Symbol: Ccnftm1.1Sje
Name: cyclin F; targeted mutation 1.1, Stephen J Elledge
MGI ID: MGI:3040863
Synonyms: Cycf-
Gene: Ccnf  Location: Chr17:24223230-24251409 bp, - strand  Genetic Position: Chr17, 12.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89060
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsFloxed exon 2 and neo cassette are removed following transient Cre-mediated recombination, leaving a single loxP site. Removal of exon 2 putatively generates a null mutation by preventing the encoding of F box as well as the creation of a frameshift mutation and a premature stop codon after encoding 5 amino acids and 39 amino acids, respectively. PCR confirmed recombination. (J:89060)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnf Mutation:  39 strains or lines available
References
Original:  J:89060 Tetzlaff MT, et al., Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol. 2004 Mar;24(6):2487-98
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory