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Tpm3tm1Pgun
Targeted Allele Detail
Nomenclature
Symbol: Tpm3tm1Pgun
Name: tropomyosin 3, gamma; targeted mutation 1, Peter Gunning
MGI ID: MGI:3040795
Gene: Tpm3  Location: Chr3:90072649-90100902 bp, + strand  Genetic Position: Chr3, 39.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89057
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA single loxP site remained in place of the first coding exon (1b) and the donor splice junction following the excision of a floxed neo cassette by transient Cre-mediated recombination. This mutation was designed to eliminate all non-muscle type isoforms of the encoded protein. Western blot showed that protein levels in heterozygote brains were the same as that of wild-type. (J:89057)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpm3 Mutation:  53 strains or lines available
References
Original:  J:89057 Hook J, et al., Gamma tropomyosin gene products are required for embryonic development. Mol Cell Biol. 2004 Apr;24(6):2318-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory