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Nkx2-5tm2Siz
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-5tm2Siz
Name: NK2 homeobox 5; targeted mutation 2, Seigo Izumo
MGI ID: MGI:3040604
Synonyms: Nkx2-5neo
Gene: Nkx2-5  Location: Chr17:26838664-26844995 bp, - strand  Genetic Position: Chr17, 13.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89216
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted into intron 1 and an additional loxP site was inserted 3' of exon 2. Northern blot indicated a 50% reduction of mRNA in mutant adult ventricular myocardium. (J:89216)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-5 Mutation:  14 strains or lines available
References
Original:  J:89216 Jay PY, et al., Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004 Apr;113(8):1130-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory