Tg(Trp53A135V)3Tgd
Transgene Detail

Summary

• Symbol: Tg(Trp53A135V)3Tgd
• Name: transgene insertion 3, Tamra Goodrow
• MGI ID: MGI:3040379
• Synonyms: p53^val135, Tg(UL53)3Tgd, UL53, UL53-3
• Transgene: Tg(Trp53A135V)3Tgd Location: unknown
• Alliance: Tg(Trp53A135V)3Tgd page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Trp53A135V)3Tgd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trp53 (MGI:98834)	Transgene codes for a protein with an alanine to valine mutation.

• Mutation details: The transgene contains the mouse transformation related protein 53 promoter and an allele of the Trp53 gene that carries a point mutation in codon 135, GCG->GTG ("Ala135Val"). (J:41667)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Trp53A135V)3Tgd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four lines were produced: 1, 2, 3, and 4.

References

• Original: J:41667 Shafarenko M, et al., Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene. Carcinogenesis. 1997 Jul;18(7):1423-6
• All: 9 reference(s)