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L1camtm1.1Vlem
Targeted Allele Detail
Nomenclature
Symbol: L1camtm1.1Vlem
Name: L1 cell adhesion molecule; targeted mutation 1.1 Vance Lemmon
MGI ID: MGI:3040294
Synonyms: L1-6D, L1camtm1.1(L1-6D)Lem
Gene: L1cam  Location: ChrX:73853780-73880838 bp, - strand  Genetic Position: ChrX, 37.43 cM, cytoband A6-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89300
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed floxed exons 12 and 14 of L1camtm1Vlem, leaving a neo cassette in intron 14. These exons encode the sixth Ig domain. Protein expression levels were similar in mutant and wild-type lymphocytes, as demonstrated by Western blot, and flow cytometry confirmed the loss of expression of the sixth Ig domain epitope. (J:89300)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any L1cam Mutation:  9 strains or lines available
References
Original:  J:89300 Itoh K, et al., Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. 2004 Apr12;165(1):145-54
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory