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Tg(TagRb)1Plm
Transgene Detail
Nomenclature
Symbol: Tg(TagRb)1Plm
Name: transgene insertion 1, Pamela L Mellon
MGI ID: MGI:3040285
Synonyms: hLHBeta-Tag, hLHB-Tag, LHbeta-Tag, LHBETATAG, LHB-Tag, TAg-RB
Transgene: Tg(TagRb)1Plm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x BALB/cJ)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene contains the human luteinizing hormone beta promoter and the wild-type alleles of the SV40 Tag and tag (large and small T antigen) genes. (J:10320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Fifteen lines were produced. In this line mice developed bilateral ocular neoplasms at about five months of age. Retinal tumors were first observed at about 2 months, and filled the vitreous cavity by 5-6 months of age.
References
Original:  J:10320 Windle JJ, et al., Retinoblastoma in transgenic mice. Nature. 1990 Feb 15;343(6259):665-9
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory