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Stat3tm3Vpo
Targeted Allele Detail
Nomenclature
Symbol: Stat3tm3Vpo
Name: signal transducer and activator of transcription 3; targeted mutation 3, Valeria Poli
MGI ID: MGI:3040161
Synonyms: Stat3deltabeta
Gene: Stat3  Location: Chr11:100885098-100939540 bp, - strand  Genetic Position: Chr11, 63.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89194
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsTo generate an allele in which the expression of the beta isoform is completely ablated while the expression of the alpha isoform is maintained, cDNA encoding the C-terminal of the alpha isoform, as well as a polyA-neo cassette, was inserted into exon 20. RT-PCR and Western blot analyses of homozygous mutant liver confirmed the absence of the beta isoform. The levels of alpha isoform transcript and protein were equivalent to those detected in wild-type mice. (J:89194)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  29 strains or lines available
References
Original:  J:89194 Maritano D, et al., The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol. 2004 Apr;5(4):401-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory