Stat3^tm3Vpo
Targeted Allele Detail

Summary

• Symbol: Stat3^tm3Vpo
• Name: signal transducer and activator of transcription 3; targeted mutation 3, Valeria Poli
• MGI ID: MGI:3040161
• Synonyms: Stat3^deltabeta
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm3Vpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89194
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To generate an allele in which the expression of the beta isoform is completely ablated while the expression of the alpha isoform is maintained, cDNA encoding the C-terminal of the alpha isoform, as well as a polyA-neo cassette, was inserted into exon 20. RT-PCR and Western blot analyses of homozygous mutant liver confirmed the absence of the beta isoform. The levels of alpha isoform transcript and protein were equivalent to those detected in wild-type mice. (J:89194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:89194 Maritano D, et al., The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol. 2004 Apr;5(4):401-9
• All: 1 reference(s)